Born in Rockville Centre, New York. She began her training with Magda Aunon at the Fort Lauderdale Ballet Classique. She then went on to study at the HARID Conservatory on a full tuition scholarship and The Central Pennsylvania Youth Ballet. In 2000, she joined the Washington Ballet under the direction of Septime Webre.
She joined Boston Ballet in 2003 and was promoted to second soloist in 2005, soloist in 2007, and to the rank of principal dancer in 2009.
Since joining Boston Ballet, she has performed a broad variety of works, including Juliet in Cranko's Romeo and Juliet, Gamzatti in La Bayadere, Giselle in Maina Gielgud's Giselle, Mikko Nissinen's The Nutcracker (Sugar Plum Fairy, Snow Queen, Dewdrop), William Forsythe's In the midde, somewhat elevated and Second Detail, Asaf Messerer's Spring Waters pas de deux, Christopher Wheeldon's Polyphonia, Twyla Tharp's In the Upper Room, Helen Pickett's Etesian and Tsukiyo, Jiří Kylián's Falling Angels, No More Play, Bella Figura, and Petite Mortå and principal roles in George Balanchine's A Midsummer Night's Dream, Serenade, La Valse, The Four Temperaments, Prodigal Son, Symphony in 3 movements, Apollo, Rubies and Diamonds.
Combes was awarded the Lefkowitz Award for Special Achievement at the New York International Ballet Competition at Lincoln Center in 2003 and she was featured on the cover of Dance Magazine in 2007.